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pentobarbital will reduce the level or result of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Not known.pentobarbital will lower the extent or result of atogepant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Suggested atogepant dosage with concomitant usage of